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Although eQTL data for rs3093105 was not available, using rs2074902 as a proxy indicated that the variation could alter mRNA expression significantly (LOD score = 2.905, p-value = 0.00025).
To test if cytoplasmic genetic variation could alter nuclear epistasis, we identified all pairs of nuclear loci that interacted with each other and the cytoplasmic genome.
We hypothesized that natural genetic variation could alter the binding site preferences and activities of ZNF transcription factors and therefore alter their gene regulatory functions.
The increased mortality in users of sulfonylurea was also shown in this paper, reminding us of the fact that genetic variation could alter responses to T2D therapy [ 155].
Genetic variation could alter gene expression via cis- or trans-acting mechanisms in a manner that impacts the functional activities of specific pathways that directly contribute to the trait [ 3].
This sequence variation could alter the types of promoter regions that transcription factors bind to, or modify protein-protein interactions, leading to differences in the signaling pathways that regulate transcription factors.
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The possibility remains that variation in IGF1 could alter insulin secretion or action as well as childhood growth.
Since common variation in IGF1 could alter circulating IGF-1 concentrations and therefore body habitus, insulin action and beta cell secretion, we sought to determine the associations, if any, between IGF1 and circulating IGF-1 concentrations, size at birth, both fasting and postprandial insulin concentrations, and type 1 diabetes.
Subtle differences in composition/conformation arising from variations in manufacturing could alter the toxicities of nanoparticles, which means that a manufacturing process that is not well controlled for highly selective parameters is at risk for variations in immunogenic potential from batch to batch.
This variation could significantly alter the properties of the bacterial cell envelope, making the bacteria more sensitive to disruptions in cell envelope integrity so that σE would be essential.
Slight variation of building orientation could alter the extent of energy consumption.
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