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All the variation carriers were heterozygous for this alteration.
Furthermore, LDLR mutational events newly reported in France represent 72% (283/391) of the unique events reported here and 41% (416/1003) of LDLR variation carriers.
Although biallelic variations predispose patients to the development of polyps and CRC (genotype relative risk: GRR of 117), monoallelic variation carriers have only a slightly increased risk of CRC (GRR of 1.27) [Tenesa et al., 2006].
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Among BRCA2 mutation carriers, no variation of BC risk was found (data not shown).
This allows for variation between carriers from the same family without modelling their dependence explicitly.
For example, Moreno-De-Luca et al.[ 39▪▪] recently reported an association between parental cognitive and behavioral profiles and phenotypic variation in carriers of de novo 16p11.2 deletions, strongly suggesting an additive relationship between inherited polygenic and de novo risk on neuropsychiatric phenotypes.
The variation of carrier frequency is known as the frequency deviation, and for very-high-frequency broadcasting it can reach ± 75 kilohertz.
This standardized geographic variations across carriers.
The variation in carrier mobility could be due to the ionized impurity scattering and surface morphology.
Open image in new window Figure 1 Variation of carrier diffusion thermoelectric power with temperature compared with experimental data.
Figs. 4 and 5 illustrate the variation of carrier concentration and Hall mobility of our samples, respectively.
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