Here, we describe the improvement of ASP-RNAi against mutant alleles carrying single nucleotide variations by introducing base substitutions into siRNA sequences, where original variations are present in the central position.
We accounted for these risk variations by introducing two additional parameters: inter-patient variation and inter-practice variation (inter-practice variation can also be viewed as correlation between patients within practices).
Next, the policy effect is imposed to be constant across quarters within a year, but allowing for variation between years by introducing year specific dummies for the policy period.
Recombination may contribute to rate variation among loci by introducing mutations [ 27, 28].
This energy-dependent time variation could be interpreted by introducing a time variation of absorption on a time scale longer than 105 s.
Temporal variations were analyzed by introducing seasonal, day-to-day, and peak concentration time variations.
Oxygen plasma treatment is utilized to rectify this limitation by introducing variation to the cross-sectional area.
We improve the GRA by introducing variation rate into the calculation of sequence difference, which enhances the correlation degree between indicators.
Consequently, environmental variation should be maximized by introducing stochasticity into the application of management fires.
Further variation of catalysts 1 by introducing different esters on the aryl group of the ureas showed that para-substitution leads to a slightly reduced selectivity (Table 1, entries 37 and 38).
In this study, we expanded the utility of the naive display library by introducing variations in CDR3 amino acid composition and length (13, 16, or 18 residues).
