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Variation between arms is shown in the normal anatomy.
Partial crossover interference was observed in at least one arm of each chromosome, with variation between arms.
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Bias is unlikely to be a major issue as this is a randomised trial, although in smaller trials important random variations between arms can occur.
Minimization of variation between study arms in albumin excretion rate, gender, age, diabetes duration, HbA1c, total cholesterol and center location will be undertaken at randomization.
Intra-individual changes in these parameters were compared for the period monitored by Virtual Hospital versus the period involving standard care (intra-arm or intra-individual variations), and variability between arms at the end of the two-year follow-up was also compared (inter-individual variations).
No items showed significant variation between hospitals within arms.
estimates (Gail et al, 1988) in case of any extra-binomial variation conferred by the randomisation of weeks between arms (1) and (2).
The observed variation in the differences between rates of miscarriage between arms in the subset of pregnancies conceived closer to vaccination is consistent with a small effect of vaccination or statistical noise.
‡Item with significant between hospital components of variation within arms of study (P<0.01).
For the GEE method, at most 1 out of 1000 simulated datasets with S-design could not converge to a solution because they either encountered a non-positive definite matrix in the iterations or because there was no variation between the clusters in each arm.
Baseline characteristics were comparable between arms.
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