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DFL harbors the t(14,18)(IGH-BCL2) translocation, which is also a common feature of NFL. 3, 6 While this translocation alone is considered necessary but insufficient to cause FL, it provides B cells with a survival advantage, allowing them to accumulate additional genomic alterations, host constitutional genetic variation, and survive in different microenvironments.
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Although the genes carry a message as precise as the digital code of a computer program, the phenotype is tolerant of variation and survives with as wide a range of genetic instructions as possible.
A fundamental property of all cells is their ability to adapt and survive despite variation in environmental conditions.
Similarly, Schulz argues, "because of errors in the replication of genetic sequences, we wind up with variation among individual members of a species; and because of that variation, the species as a whole can adapt and survive.
Chance determines the mutations and variations that survive and thrive from generation to generation.
These data verify that S. hermonthica is a highly adaptable weed that has maintained a high degree of genetic variation and plasticity, to survive in various ecosystems [ 34].
Building on that study, Chakraborty's team is using a computational model that predicts how well viruses containing different protein variations can survive and reproduce.
Yet there are bound to be many other factors at work for this variation to survive into modern times.
In these situations, allelic variation can survive multiple speciation events, leading to gene trees with branching patterns that differ from the species tree.
So, we should ask where variation comes from, how differential survival and reproductive success act on such variation and how the surviving characteristic is transmitted from one generation to the next.
Fittest variations will survive longest and will eventually evolve into new species, he realised.
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