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IDA includes mRNA expression, somatic mutation, copy number variation and phosphorylation data of ARS/AIMPs and their interacting proteins in various cancers.
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Here, we present an Integrated Database for ARS/AIMPs (IDA) that provides (i) genomic, transcriptomic and proteomic data [mRNA expression, somatic mutation, copy number variation (CNV) and phosphorylation data] of ARS/AIMPs and their interactors in various cancers and (ii) protein protein interactions (PPIs) of ARS/AIMPs.
To verify the significance of the variations of expression and phosphorylation of proteins in ATRA treated cells versus control cells, two-sided Student's t test was used.
The variation in soluble expression and phosphorylation state was marked between the four kinases as can be seen in Figure 1.
This has also been implicated to the variation in fatty acid distribution and phosphorylation status of the lipid A portion of H. pylori LPS [ 67].
We identify myeloid-specific gene expression and variations in protein abundance, isoform expression and phosphorylation at different cell cycle stages.
At first release, we did not include the PI family or their bioactive PIPx metabolites given the significant challenges associated with automating the visualization of all theoretically possible combinations of sn-1 and sn-2 carbon chain lengths, linkages, and variations in phosphorylation of the phosphoinositol head group.
For example, intraregnal variation in phosphorylation between monocotyledons and dicotyledons is smaller than the variation between M. musculus B-cells and H. sapiens macrophages.
These results suggest that variation in phosphorylation sites provides flexibility in the duration and kinetics of melanopsin-mediated light responses.
Of note, certain proteins exhibited site-selective variation in phosphorylation between different tumour types, examples being Tln1 and Cbl.
The response observed to ATRA treatment is not an on/off-like response, but a variation in phosphorylation levels.
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