Sentence examples for variation and epigenetic from inspiring English sources

While the phenotypic distinctions between SAs and other ethnicities in CVD risk are becoming increasingly clear, the biology of these conditions remains an area of active investigation, with emerging studies involving metabolism, genetic variation and epigenetic modifiers (e.g., extracellular RNA).

In addition, genetic variation and epigenetic regulation of other enzymes involved in detoxification of products of smoking may be of high interest for understanding the mechanisms behind development of RA.

There is compelling evidence that, in addition to the environmental trigger, genetic variation and epigenetic remodeling are important risk factors.

However, it has been debated to what extent expression variation and epigenetic modifications, such as patterns of DNA methylation, are transferred across generations, and therefore it is uncertain what role epigenetic variation may play in adaptation.

Recently developed sequencing technologies such as the Illumina Genome Analyzer, Roche 454 GS FLX sequencer and Applied Biosystems SOLiD sequencer have the potential to greatly improve our ability to detect ASE and to improve our understanding of cis-regulatory variation and epigenetic imprinting.

The different topics include genome-wide association studies, genome-wide complex trait analysis, copy number variations, and epigenetic analyses.

We suggest that there are three premises underlying the need for biodemographic analyses of three-generations: 1). To describe the structure of the genome, we need to use (apart from mutations) other kinds of heritable changes such as those mediated by facultative elements (variations) and epigenetic alterations.

Other genetic mechanisms that may affect WS phenotypes include DNA sequence variations and epigenetic effects originating either from WS genes expressed on the non-deleted chromosome 7 or from the remainder of the genome.

Other kinds of genetic variations such as rare or even individual SNPs, copy number variations and epigenetic modifications though maybe equally important, have not yet been targeted.

Additional factors such as germline genetic variations and epigenetic phenomena (DNA hypomethylation and hypermethylation, microRNA alterations, etc.…) were found to be associated with GIST patient outcome [ 2, 8– 12].

Tumor samples in different CIMP subclasses show distinctive correlations with gene expression profiles and recurrence of somatic mutations, copy number variations, and epigenetic silencing.