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In this study, we aimed to systematically uncover and characterize genome-wide variation affecting a major metazoan process.
DNA copy number variations (CNVs) are an important component of genetic variation, affecting a greater fraction of the genome than single nucleotide polymorphisms (SNPs).
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The second group corresponds to tumors from the clusters a and f for which it is not possible to identify a copy number variation affecting an entire chromosome arm, either because of a flat profile (cluster a) or because of a huge number of DNA breakpoints (cluster f).
These indices allow one to know how much a variation affects a given plan.
When it comes to the permanence of a population, safety is not always in numbers because environmental variation affects a population regardless of its size.
It is possible that DTNBP1 variation affects a common pathway involved in anxiety and addictive disorders.
Using systems genetics approaches, our study demonstrates how genomic sequence variation affects a unique regulatory network that is associated with macrophage multinucleation in the rat.
The p.T59R variation affected a well-conserved position in Trisk 32 and resulted in the introduction of a positively charged amino acid in the transmembrane domain of the protein.
Besides, the tool DiANNA was employed for disulfide connectivity prediction when the variation affected a Cys residue, andNetPhos2.1 (NetPhos 2.0 Server: http://www.cbs.dtu.dk/services/NetPhos/) together with Diphos (Disorder-Enhanced Phosphorylation Sites Predictor: http://core.ist.temple.edu/pred/pred.html), to predict the alteration of phosphorylation [ Blom et al., 1999].
Pathway: Search can be carried out for the variations affecting a gene featured in a specific biological pathway.
GO term enrichment for biological functions was performed as previously reported [46], in order to determine whether the observed inter-group variations affected a functional cluster of proteins sharing similar biological and molecular functions, or co-localizing in a sub-cellular compartment.
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CEO of Professional Science Editing for Scientists @ prosciediting.com