Delmont, T. O. et al. The global biogeography of amino acid variants within a single SAR11 population is governed by natural selection.
Patients that carry one or several risk variants within a given pathway may benefit from therapies that specifically target this pathway.
Here, we focus on a prototypical situation, considering only the phase transformation from austenite into all possible bainite variants within a single crystal.
The key element of our approach, the so-called variation analysis, is a methodology to identify coherent socio-technical and organizational variants within a specific innovation field.
Immunity-driven balancing selection pressure on parasite invasion proteins often results in the presence of multiple, antigenically distinct, variants within a population, leading to variant-specific immune responses.
In our study, we have used anti-Id antibodies to screen for variants within a cell line derived from a patient with a large cell lymphoma of the B cell type.
Due to the extreme rarity of some individual variants, gene-based association tests have been proposed to aggregate the genetic variants within a gene, pathway, or specific genomic region as opposed to a one-at-a-time single variant analysis.
FNANM treatment by Lewis & Ertter uses both subspecies and varieties, the latter mostly reserved for localized variants within a subspecies; 2 varieties in Rosa woodsii subsp. gratissima treated here but not in TJM2 (2012).
In this way it will address a key challenge facing cancer research in the age of precision medicine — how to identify the clonal variants within a tumor that are responsible for its growth, spread, and resistance to therapy.
The gene-specific DGGE assays were capable of producing unique, sensitive and rapid genetic fingerprints of the genetic variants within a HearNPV population and were sensitive enough to detect as many as 26 genetic variants within a single portion (<500 bp) of a HearNPV gene.
It aims at achieving economy of scope at a cost approaching that of economy of scale by delaying products differentiation and capitalizing on commonality and similarity between variants within a product family.
