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Library B provided only variants with very low stereoselectivity in the range 22 37 % ee in slight favor of (S,S -2.
Simultaneously, however, many of the cross-reactive T cells remain unable to recognize anchor-modified variants with very subtle structural differences.
Some have advocated larger GWAS (i.e., with tens of thousands of cases and controls) in order to map the common variants with very small effect sizes.
However, it has a limited ability to detect common variants with very small effect sizes and also rare variants with very low allele frequencies.
For each gene, both of the two informative SNPs are common variants with very low LD.
In order to identify such variants with very weak effects, association studies with larger sample sizes would be needed.
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Patient 7 presented with characteristic features of the Kim variant with very short metacarpals and elongated phalanges without extra ossification center.
It is thus difficult to determine whether the genetic effect at SLC2A9 is caused by a single genetic variant with very strong effect that drives the widespread association owing to extensive intermarker 'linkage disequilibrium'.
However, selective episodes driving environmental adaptation are expected to be of low frequency and intensity, leaving variants associated with very subtle functional ramifications.
A quasispecies has been defined as a cloud of mutants organized around one or a few high fitness variants and with very low Hamming distances among them.
One notes that for model variants with a very low market share, some of the predicted values are widely off the mark.
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