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By identifying haplotypes and mapping their chromosomal locations, scientists are able to associate genetic variants with specific diseases and disorders.
We also detected a large number of amino acid mutations (n = 35) that arose during recent dispersion of modern-lineage (subclade 1E) in Brazil and Venezuela, which could reflect more frequent viral replication cycles in large susceptible populations of primates from non-endemic regions and/or selective pressures for new viral variants with specific phenotypic characteristics.
In mutagenesis, TPCR is primarily advantageous for generation of combinatorial libraries of targeted mutants but could be also applied to generation of variants with specific multiple mutations throughout the target gene.
Owing to the collective and displacive nature of the austenite to martensite transformation, a certain orientation relationship (OR) between the parent and the product phase is required to minimize the transformation strain and the strain energy generated, which brings about self-accommodating groups of martensitic variants with specific orientation correlations.
Collagen XVIII (C18) exists as three amino terminal end variants with specific amino terminal polypeptide modules.
Taken together, the FAM20.1 and FAM20.2 strains express PilC1 or PilC2 variants with specific primary structures and with uncharacterised promoters.
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However, we have not yet been able to establish a causal relationship of the COMMD1 variant with specific disease phenotype since we found the variant in two patients only.
Therefore, variants associated with specific populations will be both routinely linked to other variants associated with that same haplogroup and will also be present at a significant frequency within the overall population of mtDNA sequences.
Haplotype based association analysis for identification of allelic variants associated with specific traits is considered better over single-allele studies (Johnson et al. 2001).
Furthermore, they tested whether this reseeding selects for variants endowed with specific genes driving metastasis.
The development of open-access databases of well-characterized variants associated with specific phenotypes will be essential.
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