Sentence examples for variants with significant from inspiring English sources

Advances in genotyping technologies have facilitated the advent of the genomewide association studies in large study populations and thereby led to the identification of an impressive and still increasing number of genetic variants with significant impact on the risk of widespread lifestyle health problems such as obesity, diabetes, and cardiovascular disease.

While many F-16s were produced according to these block designs, there have been many other variants with significant changes, usually due to modification programs.

A panel of VH frameworks and VH-CDR3 variants with significant improvements in affinity and expressibility were isolated by library panning.

Two consortia identified TREM2 variants with significant risk for AD [ 9, 10].

However, a large number of variants with significant associations are found in the non-protein coding regions of the genome.

To predict those variants with significant changes, tables were filtered to distinguish natural and cryptic splicing mutations (Tables S1 3).

Of the ∼85 K DHSs, ∼45 K have at least one variant with significant MAF (>0.05 across 1000G).

Interestingly, we identified several groups of three to eight genes affected by a particular STAT5 variant with significant correlated expression at distinct locations in the clustergram.

Shirley et al. (2013) evaluated the predictions of the Shannon Pipeline by manually inspecting RNAseq data for each variant with significant information changes in each cell line.

In this paper we report the development of a PML variant with significant increases in thermostability and tolerance to MeOH that retains nearly wild-type activity at ambient temperature.

For each sample we counted the number of positively selected genes, defined as those carrying at least one variant with significant DIND test in three populations or at least two variants showing outlier values both for the DIND and FST tests in the same population.