Sentence examples for variants with large from inspiring English sources

"There are no common variants with large effects," says Lavinia Paternoster, a geneticist at the University of Bristol in the United Kingdom, who plans to work with Kayser in the future on finding more facial genes.

Because of the genetic heterogeneity of HTG, a family study design is optimal for identification of rare genetic variants with large effect size because the same mutation can be observed in many relatives and cosegregation with TG can be tested.

We also demonstrate that the distribution of the observed test statistics is consistent with both rare and common variants underlying a polygenic architecture and that previous reports of linkage signals in complex traits are probably a consequence of polygenic architecture rather than the segregation of variants with large effects.

Numerous common genetic variants with small effects on blood pressure have been identified as well as some rare genetic variants with large effects on blood pressure but the genetic basis of hypertension is still poorly understood.

Sequence variants with large effects, however, may also contribute to variation in complex traits, such as circulating lipid levels.

The exponential distribution of Vg is compatible with numerous rare variants with large RR or numerous common variants with small RR, or a combination of both.

It should also be noted that ExAC does not include variants with larger deletions or duplications due to technical reasons.

The blanket variants with larger radial breeder zone show better shielding performances due to the reduced Eurofer shielding material acting as gamma radiation emitter in between the breeder zone and the vacuum vessel.

As a result, variants with larger effects are over-represented and the Vg of the discovered variants would not follow a standard exponential curve.

In general, novel resistant clones will need to adapt and survive in the novel environment, and hypermutable organisms could have an advantage for such adaptation (Baquero et al. 2004; Perron et al. 2010; Wang et al. 2013) resulting in the selection of variants with large-effect mutations over those brother variants of small effect (clonal interference) (Barroso-Batista et al. 2014).

Rare variants with larger effects have been found in a number of genes leading to syndromic short stature disorders.