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Finally, we applied the strict mask to obtain a set of variants with high accuracy.
He is a member of the International Inflammatory Bowel Diseases Genetics Consortium (IIBDGC) and has co-led its recent fine-mapping effort to resolve known genetic associations to variants with high causal probabilities (Huang et al., Nature, 2017).
Schizophrenia is a neuropsychological disorder with a strong heritable component; genetic risk for schizophrenia is conferred by both common variants of relatively small effect and rare variants with high penetrance.
Previous Photinus pyralis red-emitting variants with high Km values for ATP have performed disappointingly in live cells despite having much higher relative specific activities than enzymes like Click Beetle Red (CBR).
We successfully achieved the separation of acidic, main and basic charge variants with high recovery (>70%) and purity (>90%) by using a commercially available stationary phase in conjunction with a commercially available displacer.
Success in these disorders raises hope to find specific rare variants with high relative risk in migraine families.
These compensatory mutations can generate variants with high transmission fitness (δrH), comparable to that of the wild-type strain.
We found that some early CTL responses could cross-recognize their variants with high magnitudes even before the variant sequences were abundant in the viral population.
Thus, all sequence variants with low peaks were attributed to one, whereas variants with high peaks were attributed to another haplotype (see Figure S1).
Using a statistical variant caller for pooled sequencing data, CRISP[12], we were able to detect single nucleotide variants with high sensitivity and specificity.
Recent work investigated binding of A-Beta to several TTR variants; TTR variants with high amyloidogenic potential bound poorly, whereas more stable variants had a higher affinity for A-Beta [19].
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