Sentence examples for variants with elevated from inspiring English sources

In conclusion, despite the limited power of the study, here we have replicated the association of TLR1 gene variants, with established increased NF-κB activation in vitro, with risk for circulatory dysfunction during severe sepsis, and associated TLR1 variants with elevated CRP and decreased IL-10 levels in serum during the first week of sepsis development.

We also selected P AOX 1 promoter variants with elevated expression level under induced conditions.

Co-segregation of the variant with elevated lipid levels in relatives would strengthen the inference that they are FH-causing.

Of note, TCF7L2 variants are associated with elevated blood glucose.

In conclusion, our genetic analyses revealed that germline SDHx variants are associated with elevated cancer risks in CS/CSL individuals, both alone and synergistically with germline PTEN mutations.

Other studies have reported that these two XRCC1 variants are associated with elevated risks of esophageal cancer [ 15], pancreatic adenocarcinoma [ 16], and breast cancer [ 17].

In our 2012 study, we validated that germline SDHx variants are associated with elevated thyroid cancer risks in Cowden and Cowden-like individuals.

We have shown that CS-related SDHx variants are associated with elevated reactive oxygen species (ROS), hyperactivated hypoxia-inducible factor (HIF), induced lipid peroxidation and disrupted mitochondrial metabolites in CS/CSL patient-derived lymphoblastoid cells (18).

Although serine and phenylalanine are amino acids with different chemical properties, several lines of evidence indicated that the S86F Fallele allele was functional, including detection of delta-twelve fatty acid desaturase activity in a yeast recombinant expression experiment and no association of the S86F Fallele allele variant with an elevated oleic acid phenotype (data not shown).

The rs10229583 risk variant was associated with elevated fasting plasma glucose, impaired beta cell function in controls, and an earlier age at diagnosis for the cases.

The minor risk allele of the CDC123/CAMK1D rs12779790 variant was nominally associated with elevated fasting serum insulin additive model: p = 0.07 (Table S4) and recessive model: p = 0.05 (adjusted for sex, age, BMI and fasting plasma glucose).