Sentence examples for variants with compromised from inspiring English sources

The engagement of immune cells by trastuzumab through Fc gamma receptors (FcγRs) was tested using three trastuzumab variants with compromised or no Fc (fragment crystallizable) functions and FcγRs blocking experiments.

Deletion of only a portion of FUS RGG3 motif in dRGG3 protein does not affect frequency of cells with different types of the protein distribution in the cytoplasm compared with FUS variants with compromised NLS but intact RNA-binding domains, e.g. FUS R522G (compare Fig.  1F and Fig.  6E).

These data highlight the need for a range of functional studies to be performed in order to identify variants with partially compromised function.

This analysis confirmed that the Hop/Sti1 phospho-mimetic variants are indeed compromised in their interaction with Hsp70.

To be consistent with this mechanism, the C104 ISCU2 variants, which are compromised in FXN-based stimulation, would need to adopt a conformation different from that of either native ISCU2 or the other ISCU2 variants.

The emphysema-associated TERT variants compromised telomerase catalytic activity, and mutation carriers had abnormally short telomeres [ 50].

In contrast to these latter variants, our data suggest that the G787R variant is functionally compromised and may be a rare cause of hereditary colorectal cancer.

To test this possibility, we assessed the CO exchange with two site-directed variants of recombinant CODH-II (CODH-IIHT): K563L, which is an acid−base variant that is compromised in generating CO2 from CO (36), and C56A, which lacks a functional B-cluster, allowing it to generate CO2 but disabling electron transfer to external redox mediators.

These variants may compromise protein function and contribute to the PIBD phenotype in these patients.

Fluorescence loss in photobleaching analysis showed that the A436T variant compromised stability of lamin B1 interaction within the lamina.

The yield of MC4R testing in clinical diagnosis and treatment of obesity is at present undefined since the relatively low prevalence of MC4R pathogenic variants in the general population, along with the high number of sequence variants, has so far compromised the devising of systematic controlled intervention studies.