Sentence examples for variants with all from inspiring English sources
Substitutions were made at six neighboring sites in the major hydrophobic core of staphylococcal nuclease to create variants with all leucine, all isoleucine or all valine at these sites.
A straightforward and complementary approach to measure fitness interactions relies on the construction of HIV variants with all mutations along an evolutionary pathway, then measuring their individual and combined fitness effects, and comparing the results with predictions generated under the null hypothesis of non-epistatic interactions [18].
We also found that strong selective pressure was driving the emergence of new M-protein variants, with all but one of the new alleles encoding amino acid substitutions.
Thus, we compared EFIN with HumVar-trained PolyPhen-2 on a subset of Swiss-Prot variants with all HumVar mutations excluded (Table 3).
The Mandenka share E3a*-M2 variants with all other groups in Guinea-Bissau and do not match types outside Central-West Africa (except H67 in Mozambique), a sign of localized expansion and increased influence over their ethnic neighbors.
The in silico analysis suggested a possible deleterious effect of only five missense variants with all prediction programs (c.1067A > G, c.1648A > C and c.3113A > G in BRCA1 and 3515C > T and c.6100C > T in BRCA2) (Table 6).
An m36 variant with all five mutations in the FRs reverted back to germline showed slightly increased neutralizing activity against two HIV-1 isolates tested.
The crystal structure of the variant with all three stabilized turns confirms that the 157 163 loop was in fact shortened to a type I′ turn and that the other turns maintained their type I′ conformation after sequence optimization.
Replication analyses of this variant in 1,142 Caucasian patients with eating disorders from five European countries confirmed the association of this variant with all eating disorder subtypes including AN, AN-restricting type, AN-binge-eating/purging type and BN [ 53].
Additional experiments were performed with sequence variants of Pep19-2.5 Pep19-2.5e duplicated form, Pep19-2.eDup, the variant with all amino acids in a D-configuration (Pep19-2.5D-AA), and a varianthen which the final sequence at the C-terminus is lacking (for sequences see Table 1).
In contrast, it is not feasible to evaluate accuracy among all potential variants associated with all known diseases captured on an exome-wide or genome-wide basis.
