Sentence examples for variants will lead from inspiring English sources

Nevertheless, we fully expect that additional variants, some rare, will be added to the growing list of polymorphisms that influence T2D, and that the analyses of interacting variants will lead to a better understanding of the biological pathways underlying T2D.

The actual number of truly associated variants is usually larger than that predicted by local fdr when z is around 0. Inclusion of all variants will lead to an underestimation of mean Vg, as the weights for SNPs with z-values around 0 will be inappropriately low.

With the continuous decrease in sequencing cost, new studies making use of WGS to investigate causative variants will lead to the discovery of additional mutations in regulatory elements that contribute to the pool of disease-associated variants.

The study of natural variants will lead to the development of methods for improving efficacy and safety of the extracts currently in use for diagnostic and therapeutic purposes, as well as the routine trials for quality control of many laboratories.

Perhaps of more importance, the discovery of the selected variants will lead to the identification of large effect QTLs and ultimately a better understanding as to the phenotypes which are affected by variation within genes and regulatory elements.

First, in contrast to the missense mutation, the frameshift variant will lead to a completely altered protein sequence and structure.

One must also be cautious in assuming that a null variant will lead to disease if found in an exon where no other pathogenic variants have been described given the possibility that the exon may be alternatively spliced.

Analysis of additional larger samples, and the use of genome-wide association and high-throughput variant detection will lead to the identification of further genes for ASDs.

Therefore, any threshold applied to filter out variant signal ratios will lead to disregard of some variant regions because their signal ratio is not changed enough (false negatives) and on the other hand detection of unchanged regions that show for some reason a variation to a lowered signal ratio (false positives).

However, the time-variant hardware delays will lead to TIFB if the third frequency is used.

A drug that simultaneously inhibits different variants of the target will lead to a faster suppression of the virus, retard the appearance of drug-resistant mutants and provide more efficacious and, in the long range, more affordable therapies.