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SPAK appears to activate NCCT by phosphorylating key residues in its amino-terminal region, so functional SPAK variants will affect salt uptake by the DCT and hence BP.
9 The aim of the study was to determine the relationship between the G894T polymorphism of the eNOS gene and the BgI II polymorphism of the ITGA2 gene and susceptibility to DR and to determine whether their genetic variants will affect the type of retinopathy.
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Therefore, this variant will affect the Q value.
The rs1051730 variant will affect smoking heaviness of the mothers throughout the period that they continue to smoke and so will influence the heaviness of smoking during childhood.
Also, as this study was performed by overexpression of one variant of HGFIN, it is unclear how the extra 12 amino acid insert between exons 1 and 2 in the extracellular domain of the other human variant will affect the biology reported in this study [29].
Other wild felid-specific variants will likely affect tabby patterning (Kaelin & Barsh 2010) as well as other aspects of colouration and morphological variation, each potentially affecting the accuracy of genetic tests.
The larger effect variants will likely affect proteins, whereas regions in gene deserts or regulatory elements are more likely to have small effects on a trait or a disease – they likely contribute, but won't be where the gold is, so to speak.
As the design of the primers and probes for gene expression measurement is usually based on the gene sequence information from the RefSeq and non-RefSeq databases, any inaccuracies in those databases or the presence of previously unknown SNPs or splice variants, will potentially affect the accuracy of the assays.
We next used this panel of five NA variants to determine how substitutions that abolish hemadsorption activity will affect the enzymatic activity of the NA.
Site density will affect the ability to resolve recombination breakpoints and overall number of variants discovered.
"This will affect Kirkuk".
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