Sentence examples for variants which affect from inspiring English sources

Additional genetic variants which affect clopidogrel metabolism have recently been identified.

These SNPs might serve as variants which affect the binding specificity of the Cbf gene family.

Except for FTO and MC4R variants, which affect T2D susceptibility through their effect on BMI, none of these loci overlap with the known T2D loci (Fig.  1) [ 50].

While the standard association test considers genetic effect on phenotypic means, a test of genetic effect on phenotypic variance has been developed and applied to detect genetic variants which affect gene expression levels [ 34, 35] and quantitative traits [ 33, 36].

This concern was supported by a recent study using oligonucleotide microarrays that identified a dramatic lack of concordance between differential expression results analyzed with or without masking sequence variants, which affected approximately 16% of the array's probe sets [ 1].

Therefore the BDNF Val66Met variant, which affects secretion of BDNF, may interact with early exposure to pain-related stress in children born very preterm, to differentially affect HPA regulation that in turn may be associated with altered cognitive performance.

We initially hypothesized that a variant which affected stability of the triplet repeat lying up to 75 kb distal might be a relatively large deletion or insertion that would affect the chromosomal structure or perhaps remove or insert a putative stability modifier.

By causal variant, we mean any source of genetic variation which affects the phenotype (here, epilepsy susceptibility).

C-myc/IgH translocations, for example, are completely dependent on AID activity and recent advances in genome-wide translocation analyses have revealed many AID-dependent translocation hot spots 5– 7. Recent studies have shown that several alternatively spliced AID variants exist, which affect the C-terminal part of the AID protein, while the N-terminal exons 1 and 2 are preserved.

In the case of modularity, it means that among gene variants that affect different numbers of traits, those gene variants are selected which affect lower numbers of traits, as well as certain combinations of traits.

Given the high rates of diabetes and nephropathy, especially in Asian populations, the use of biomarkers such as variants of the ALR2 genotypes, which affect 30% of the population, may identify high-risk subjects for intensive and targeted preventive therapy.