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However, it was observed that, collectively, rare TLR4 variants were overrepresented in the patient population.
Rare variants were overrepresented in patients compared to controls (34 patients/14 controls; P = 0.0001; Table 1 and Supp. Table S4).
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In the second, we categorize variants selectively into two subsets: one in which variants are overrepresented in cases, and the other in which variants are overrepresented in controls.
The number of damaging variants is overrepresented in the faster evolving copies of asymmetric genes (p < 0.001) and underrepresented in the slower evolving copies (p < 0.001) compared to the set of non-asymmetrically evolving gene pairs.
Similar results were obtained on analyzing allelic distribution: the number of 3R variant was decreased in class 1 and 3 and increased in class 2 and 4, while the 4R variant was overrepresented in class 1 and 3 and underrepresented in class 2 and 4 (χ2 = 16.0; df = 3; p = 0.001).
The variant is overrepresented among our obese subjects (MAF 8%).
Acknowledging that histopathological distinction of GBM-O from small cell glioblastoma can be difficult, it is likely that the latter variant was overrepresented in some studies taking glioblastomas as a starting point, particularly given their reportedly high frequencies of EGFR gene amplification.
However, GO term of oxygen binding (GO 0019825) was only enriched in the data set showing differential expression at gene level, whereas two categories of protein binding (GO 0005515) and nucleotide binding (GO 0000166) were overrepresented in that with differentially expressed splice variants.
At gene level, genes involved in two biological processes of carbohydrate metabolic process (GO 0005975) and transport (GO 0006810) were overrepresented, but there were no enriched GO terms of biological processes for these genes with differentially expressed splice variants.
Boys as a group were overrepresented.
Of the nonfamily crows tolerated, juveniles were overrepresented.
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