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In contrast, the wild type NL4-3 and the bevirimat resistant variants were equally sensitive to the HIV-1 RT inhibitor AZT.
However, this effect was not isoform specific since all three LAMP-2 variants were equally effective in abolishing the late endosomal/lysosomal cholesterol accumulation [ 10].
Importantly, the observed lack of 1-indanone conversion is not caused by a poor expression because all PAMO variants were equally well expressed under these experimental conditions (data not shown), thereby pointing towards a low reactivity of PAMO P440L and P440G with 1-indanone like the wild-type enzyme and possibly a lowered uptake of the substrate under non-optimized conditions.
Similar(57)
The two variants are equally distributed — about half of people have one and half have the other.
MN14C11.6, a reference monoclonal antibody for serosubtype P1.7 epitope located in predicted loop 1 (VR1) identical in all the variants, was equally protective against all loop 4 variants.
Therefore, the two variants are equally likely to be responsible for the observed pathogenic effect.
Likewise, each of the variants was equally sensitive to trypsin in the presence or absence of Ca2+.
The detection limit for haplotypes is the haplotype frequency at which observed variants are equally likely to be errors (co-occurring within reads due to chance) or biological variants (corresponding to a true haplotype).
However, in cases where such information is unavailable (e.g., all variants are equally rare), the accuracy of VAAST 1.0 drops, while VAAST 2.0 still accurately predicts the severity of variants using the CASM method.
This may suggest that complement variants are equally important for the development of both forms of late AMD, and additional genetic and/or environmental factors may be required to determine if either geographic atrophy or CNV develops.
For example, smokers with the Asp40 variant of the mu-opioid receptor gene had double the quit rate with higher-dose nicotine replacement therapy (NRT) than with lower-dose NRT, while smokers homozygous for the more common Asn40 variant were equally likely to stop smoking regardless of NRT level [ 1].
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