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For each enzyme two inhibitor variants were designed.
The structural and functional significance of these interfaces was probed by solution NMR and disruptive variants were designed and tested for DNA deaminase and anti-HIV activities.
For this purpose, four different Fab fragments with different CDRs and/or framework regions of the variable domains were identified and related variants were designed in silico.
In this study different HCV structural region variants were designed to express the first 120 aa, 176 aa, 339 aa, and 650 aa of HCV polyprotein, and aa 384 to 521, or aa 384 605 or aa 384 746 of HCV E2 protein fused to the leader sequence of sucrose invertase 2 allowing the secretion of recombinant E2 proteins.
Other variants were designed by Viquesney to depict different doughboy poses, but very few got past the drawing stage and none were ever realized at full scale.
Gene variants were designed by back-translating the protein sequence using a Monte Carlo repeated random sampling algorithm [19].
Similar(35)
The separation of the MAb variants was designed for an isocratic and a linear salt gradient operation.
These variants are designed to provide unique labeling sites for probes to be used in spectroscopic experiments investigating the mechanism of proton pumping in CcO.
In order to address the high cost of this practice, manufacturers develop product families with a common platform, whose variants are designed to meet different customer demands.
Using the docking software HADDOCK, a virtual library of peptide variants was designed and screened in-silico against the known HWRGWV binding site on the pFc fragment of IgG.
These variants are designed heuristically, based on the analysis of the existing urban transportation system and evaluated by a consistent family of criteria which takes into account interests of different stakeholders.
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