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Colony morphology variants were caused most frequently by the inactivation of metabolic genes.
By comparing sequencing of the transcriptome (RNA-seq) with the genome, the authors were able to identify alterations in two transcripts (COG3 and SRP9) that result in variant protein sequences not encoded by the genomic tumour DNA, suggesting that these variants were caused by RNA editing.
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If the variants were causing lethality due to, for example, unregulated access to stalled replication forks; it should be observed independent of both the treatment and the dinB deficient allele tested.
The heterogeneous formation of different ω variants is caused by a heterogeneous distribution of Zr + Nb elements across B2, which plays an important role in stabilizing vacancies and promotes the formation of D88-ω.
LND and its variants are caused by different mutations in the HPRT gene (Table 6).
Whether these variants are caused by mutations in fleQ, wspA, or wspE homologs in P. lipolytica remain to be explored.
The observation of readily detectable levels of apocytochrome of the F15A and F15E variants in cytoplasmic extracts suggests that the lack of heme attachment to these two variants is caused by loss of recognition by HCCS, rather than structural instability of the proteins in either the apo or holo forms.
Ransomware variants are causing havoc across global networks, but this week saw the emergence of Locky, not a particularly sophisticated malware but one that's spreading fast.
It is therefore unlikely that any of these variants is causing the disease phenotype.
Judging by the scanning calorimetry data, the increased stability of the folded structure of the new SH3-variant is caused by entropic factors, since the changes in heat capacity and enthalpy upon the unfolding of the wild-type and mutant proteins were identical at 298 K.
The phenotype of the rupintrivir-resistant variant was caused by a single amino acid change, G128Q, in the 3C coding region.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com