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We found that all examined hAID variants were able to deaminate 5 mC, and all of them failed to deaminate 5 hmC.
All variants were able to activate allergen-specific T cells in PBMC, as well as Art v 1-specific T cell lines and clones.
It has been found that six out of seven frequent variants were able to cause the invalidation of famous neutralizing MAb 2F5.
Polyclonal antibodies produced against the simplified variants were able to recognize the parent peptide, but not the opposite simplified forms, in strict agreement with the model of independent surfaces of recognition.
However, these variants were able to suppress aggregation during arginine kinase (AK) refolding as efficient as wild-type rhCyPA, especially, variant Q63A had even more efficiency to suppress aggregation and improve reactivation yields of AK.
In a bacteria-delivered model for enzyme prodrug therapy, the engineered FRase I variants were able to kill human colon carcinoma (HCT-116) cells at significantly lower CB1954 concentrations than wild type FRase I or E. coli NfsB.
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All the edge variants are able to form amyloid fibrils when they are incubated at their melting temperatures.
Such STING variants are able to secrete type I IFN spontaneously and activate an IFNβ Luciferase reporter construct without exogenous addition of STING stimuli19.
Boosting algorithms (Adaboost and variants) are able to construct a strong classifier as a linear combination of weak classifiers (here a single threshold) chosen from a given, finite or infinite, set, as shown in (3): (3).
Dominant-negative Ush variants are able to induce lamellocyte differentiation and it has been suggested that Ush regulates lamellocyte differentiation from a potential plasmatocyte [22].
The ability of some isolates to overcome RB-mediated resistance raised the possibility that specific IPI-O variants are able to suppress responses induced by activation of RB.
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