Sentence examples for variants we show from inspiring English sources

As further evidence for the presence of the different transcript variants, we show a piling of RNA-seq reads on a pair of isoforms in Pru and RH.

Using NMR data of plasma samples from 1,757 individuals from the KORA study together with 655,658 genetic variants, we show that ratios between NMR intensities at two chemical shift positions can provide informative and robust biomarkers.

In the framework of the new model variants, we show that the TFBSs with the strongest impact on gene expressions appear in all domains of the regulatory regions considered in the model.

By using an Escherichia coli β-galactosidase variant, we show that aggregation does not necessarily require unfolded polypeptide chains but rather depends on specific interactions between solvent-exposed hydrophobic stretches in partially structured species.

Using the HID28 variant, we show that docetaxel treatment of tumour-bearing mice induces an increased HER2 mRNA expression of the tyrosine kinase receptor of 25-fold 24 h after docetaxel treatment, while HER2 protein and p-AKT decreased.

Previous studies related to ncRNAs show noncoding genes, such as XIST (Duret et al. 2006) or HOTAIR (Rinn et al. 2007), but not much is known about coding genes with alternative noncoding splice variants, as we show in this study.

Of course, it was already known that a better matched reference set will result in better imputed genotypes; however, the results from this paper were based on low-frequency variants and we show that there is also an inter-European effect of reference sets.

Finally, despite partial loss of expression from the variant allele, we show that the c.-28A>G and c.-7C>T variants are not associated with promoter hypermethylation or alterations in nucleosome occupancy.

Here, we investigate the mechanism of cleavage and release of the 49 127 fragment from the prototypic S52P variant, and we show that the proteolysis/fibrillogenesis pathway is common to several amyloidogenic variants of transthyretin and requires the action of biomechanical forces provided by the shear stress of physiological fluid flow.

Using multiple ChR2 mouse lines that expressed the common ChR2 variant (H134R), we show both ex vivo and in vivo that light-induced neuronal firing can be accompanied and/or followed with periods of latency in various neuronal subtypes.

Although it is well accepted that each cancer sample is different and only a small fraction of variants are recurrent, we show that with mutations recurring more than 30 times (53 variants) explains a comparatively large fraction of patients (~40%).