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We compared HIV-1 Gag-specific T-lymphocyte responses in 20 HIV-1-infected individuals representing two different HIV-1 subtypes, B and C. By assessing T lymphocyte responses with peptides based on natural HIV-1 variants, we found evidence for limited cross-reactivity and significantly enhanced within-clade responses among clade B-infected subjects, and not among clade C-infected subjects.
However, when we comprehensively evaluated all HapMap SNPs in linkage disequilibrium with those genetic variants, we found that 54.1% of loci were associated with adult height in our sample of African Americans.
In TLR4 variants we found 22 rapidly evolving positions distributed all over the LBR.
Among class A variants, we found missense, splicing and frameshift RRA loci in COL4A1, PIGN and ATM genes.
In contrast, the mild variants we found enabled us to ask whether more Hsp83 means better buffering [ 53].
Some of the variants we found in severely obese individuals are also found in publicly available exomes (Table 1).
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Using engineered trypsin variants, we find similar overall binding modes for the (E,Z) and (Z,Z) isomers.
For some variants, we find that the distribution of response time can be decomposed into the sum of response time for a server farm without setup and the setup time.
We believe the majority of the variants we find are genuinely acquired somatically.
Following extensive checks on genotype quality and after excluding poorly clustering variants, we find replicating association of rare variation at the TNFAIP3 locus with RA susceptibility.
Similarly, in the CDS class (the protein coding sequence class which includes both synonymous and missense variants) we find 7 dairy traits to be significantly enriched while for the beef traits we see only the trait LLPF to be enriched.
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