Sentence examples for variants we focused from inspiring English sources

To identify novel transcript variants, we focused on intronic 3'-end exon sites.

To address age-independent differences between the Drosophila variants, we focused on genes that show a consistent up- or downregulation in both middle-aged and old SR flies.

In order to isolate theses putative variants we focused on exon 3, which showed seven polymorphic sites, including four informative sites that differentiate the three patterns found in the sample of sires.

On the basis of intensive literature review and mutation prediction of these genetic variants, we focused on a heterozygous mutation (p.Asp208His/D208H; c.622G>C), reference sequence NM_182476.2) of the COQ6 gene, whose function is essential but not redundant.

To rank the remaining participants based on variants, we focused our analyses on 27 genes (Table 2) deemed either as actionable by CPIC [ 4], or as important drug targets based on preliminary association data to pharmacological traits [ 3].

To identify potentially pathogenic mutations among called variants, we focused on rare (e.g. not annotated in dbSNP130, 1000 Genome project, or Exome Variant Server, ESV) non-synonymous (NS) variants, splice-site variants (SS), and short coding insertions or deletions (indels; I).

Based on the EvolSimulator results reported above, these LP approaches (particularly the rLP and ndLP variants we focus on) are better able to recover strong, distinctive vertical and lateral inheritance patterns than are network approaches that make direct use of BLASTP similarities.

Of the 24 novel coding variants identified, we focused on the R225W mutation due to the established importance of the mutation in porcine AMPK γ3 and the homologous mutations in the γ2 subunit of human AMPK.

To detect such variants, we have focused on the development of an approach that investigates functional protein-protein interactions encoded by genes within the HLA region.

For the assessment of potentially multifunctional variants we therefore focused on markers with inverse effects.

Since no additional informative sequence variants were identified, we focused on the detection and sequencing of pre-mRNA transcripts about 1 kb downstream of the transcription initiation site in GM7007.