Sentence examples for variants we find from inspiring English sources
Using engineered trypsin variants, we find similar overall binding modes for the (E,Z) and (Z,Z) isomers.
In addition to these 10 coding variants, we find 21 associations beyond the MC1R coding region at distances up a megabase both 3′ and 5′.
Including this variant, the two newly associated missense variants described above and 13 previously described coding variants we find that the proportion of red-haired individuals with two MC1R alleles is 92%, whilst only 6.3% carry a single allele.
For some variants, we find that the distribution of response time can be decomposed into the sum of response time for a server farm without setup and the setup time.
However, to better compare the results we looked for significant associations within fixed genomic distances from the 137 of Hysi et al. Within 10 kb of their associated variants we find 93 associations, and within 100 kb we find 100 (Supplementary Table 6).
This has impact on how we interpret the significance of the variants we find.
Although additional formal genetic experiments are required to definitively demonstrate that we have identified the causative variant, the findings presented here are strong evidence that the replacement variants we found are the best candidates.
Besides established variants, we found certain unreported variants at sub-genome-wide level QKI, REEP3, TMCC2, FAM129C, FAM241B, and LOC100506207.
Similarly to what we observed in the candidate variants, we found some variability between expected vs. sequenced SNPs, with a slight mismatch of the variants present according to expected values (Supplementary Table S2).
We compared HIV-1 Gag-specific T-lymphocyte responses in 20 HIV-1-infected individuals representing two different HIV-1 subtypes, B and C. By assessing T lymphocyte responses with peptides based on natural HIV-1 variants, we found evidence for limited cross-reactivity and significantly enhanced within-clade responses among clade B-infected subjects, and not among clade C-infected subjects.
However, when we comprehensively evaluated all HapMap SNPs in linkage disequilibrium with those genetic variants, we found that 54.1% of loci were associated with adult height in our sample of African Americans.
