Sentence examples for variants we detected from inspiring English sources

Direct conservation of mutated residues in our families is not evident across such a large evolutionary divide, but four of the five familial variants we detected lie near or within predicted active site regions of the bacterial enzyme based on molecular modeling and multigenome alignment (Fig. 5)[28].

In the present study of the isolate sequenced, which was a mixture of variants, we detected 17 positions distributed along the genome that were highly polymorphic (variable in more than 20% of the reads; Fig. S1a), all of which were silent or neutral nucleotide (nt) substitutions.

Several selected variants we detected map within ENCODE functional elements (fig. 4).

To assess the extend to which the population specific variants we detected are false-positives, we used PCR followed by Sanger sequencing.

Intriguingly, upon filtering out non haplogroup-defining variants, we detected a widespread population occurrence of rare events predicted to be damaging.

With the expression of all 47 MUTYH variants, we detected EGFP signals at a similar intensity as that observed with wild-type MUTYH.

Therefore, to determine the validity of the 'variants' we detected at the very lowest thresholds (0.1 0.5%), an ANOVA was performed to compare the distribution of stereotyped variants between MNGIE and control mtDNA.

Last, to validate our filtered set of HLOF variants, we Sanger-sequenced any novel variants that we detected in our samples; these included 33 variants which were neither found in the set of HLOF variants of (2) nor (7), and had no validation record in dbSNP.

However, proportional to the number of variants analyzed, we detected far fewer low-frequency variant associations than common variant associations despite the same statistical power to detect individual variants explaining the same proportion of phenotypic variance.

Among the variants that we detected, 35INS is best studied in the literature.

No other variant that we detected within a 1-Mb window had a substantially more significant eQTL.