Sentence examples for variants we designed from inspiring English sources

In order to facilitate the identification of causal variants, we designed a simple computational method called the "preferential linkage disequilibrium (LD)" approach, which follows the variants discovered by GWASs to pinpoint the causal variants, even if they are rare compared with the discovery variants.

Given the chromosomal position of variants, we designed PCR primers to amplify fragments harboring individual variants by Primer3 [ 36].

To measure the wild-type function or a putative dominant deleterious effects of each of the rab7 variants we designed a quantitative population experiment.

In order to accurately detect and characterize genomic structural variants, we designed a streamlined workflow (summarized in Additional file 2: Figure S1) as follows: The overall quality of the WGS reads was assessed using FastQ.

To assess the expected number of suspected positions in randomized variants we designed the following procedure, named One-Versus-Rest (OVR) model: in each randomized MFE-profile, the suspected folding related signals were identified by a position-wise comparison to the rest of the randomized MFE-profiles from the same wild-type origin.

For each model variant, we designed a selection experiment to identify the best configuration of parameters as the one that achieves the minimum expected predictive error.

To obtain a quantitative measure of global histone turnover as a function of modification status and type of sequence variant, we designed a time course experiment using stable isotope labeling with amino acids in cell culture (SILAC) in conjunction with high-resolution mass spectrometry (MS).

Lamellar techniques turned up at the horizon with descemet stripping automated endothelial keratoplasty (DSAEK) as the most prominent variant when we designed FANCY.

To determine whether this deletion was associated with genotype and therefore caused by the variant rs11078928, we designed Taqman assays to the wild-type and novel transcripts as described above from the custom assay service available from Life Technologies Life Technologiess, Foster City, USA).

To further investigate possible use of the alternative splice acceptor site in exon 13 of mesothelin, as reported in variant 2, we designed primers in exons 12 and 13 (Table 1, 24 bp insert) and amplified RNA from various cell lines and tissues.

While evolving a lipase in vitro from mesophilic Bacillus subtilis to generate thermostable variants, we have designed protocols that combine stringent three-tier testing, sequencing and stability assessments on the protein at the end of each generation.