Sentence examples for variants we created from inspiring English sources

By changing the number, frequency, and ORs of simulated variants we created baseline models with an AUC ranging between 0.50 and 0.95.

Given the small number (n=5) of nonsense variants, we created a 'coding nonsynonymous' designation by combining the 'missense' and 'nonsense' categories; similarly, we combined the 'untranslated 3', and 'untranslated 5' designations into the category 'untranslated'untranslated

Then, to directly assess the clinical relevance of candidate variants, we created genetic scores using the top 10 single nucleotide polymorphisms (SNPs) to test whether carrying more protective alleles was associated with greater gray matter (GM) volume in an independent group of cognitively normal older adults.

To investigate the impact from the nonsynonymous variants on TGR5, we created a receptor model, and introduced mutated TGR5 constructs into human epithelial cell lines.

To assess the location of the two splice variants of QSOX1, we created stable cell lines expressing each protein tagged with a V5 epitope at the C-terminus.

The descriptor sets included in the study are Z-scales (3 variants), VHSE, T-scales, ST-scales, MS-WHIM, FASGAI, BLOSUM, a novel protein descriptor set (termed ProtFP (4 variants)), and in addition we created and benchmarked three pairs of descriptor combinations.

Finally, we created variants by site-directed mutagenesis combining single mutations or changing residues in the Jα helix.

To test if we can generate a 'super-active' substrate sequence by combining the best substitutions at these positions, we created three variants with double-substitution (FVVLQ↓SGF, TVVLQ↓SGF and VVVLQ↓SGF) and three variants with triple-substitution (FVRLQ↓SGF, TVRLQ↓SGF and VVRLQ↓SGF).

To understand the contribution of individual domains to the function of CMTr1 and CMTr2, we created deletion variants of each protein.

We created random variants of the 3p shRNA sequence using an oligo synthesizer and spiking each phosphoramidite (A, C, G, T) bottle with the other three ("spiked oligo synthesis") [29] at a low concentration designed to generate ∼1.5 mutations per construct after annealing the two complementary DNA strands.

We created two variants of the task illustrated in Fig.  1.