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Although the fluorescent response of the aptamer variants was highly dependent on experimental temperature, we have found one of the variants showing suitable fluorescent response by titration with adenosine.
No variants were identified in the NADH dehydrogenase 1 (ND1) gene or the 22 tRNAs suggesting that the incorporation of variants was highly selective to the other 12 coding genes and the D-loop region.
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While activation measures in the inhibitory networks of both delay variants were highly comparable, the neural responses to fixed delay trials were more variable across participants.
Proline-substituted FR-15 variants were highly selective toward bacteria and fungi over hRBCs and murine 3T3 cells and also retained their antibacterial activities at high salt, serum and elevated temperatures.
Probe sets that detected potentially alternatively splice variants were highly correlated with over 80% with correlation coefficients over 0.5.
Due to the use of Monte-Carlo sampling in the gene design, all of these variants were highly divergent in sequence identity from each other.
Comparison of ankyrin-B protein primary sequence from different species (Figure 1B) shows that the identified variants are highly conserved in vertebrates.
Therefore, predicted functional variants are highly correlated with disease phenotype, which justifies the importance and attests to the feasibility of identifying putative functional variants prior to grouped association analyses.
In contrast to A-type RIFINs, the expression patterns observed for B-type RIFIN variants were highly consistent between all three experiments and indicated strict regulation during sexual differentiation (Table 3, Fig. 6).
Two of the de novo missense variants are highly likely to be pathogenic.
These variants are highly likely to be expression quantitative trait loci (eQTLs).
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