Sentence examples for variants was consistent from inspiring English sources
Definition of pathogenicity for BRCA1 sequence variants was consistent with the policy of the Breast Cancer Information Core database (http://research.nhgri.nih.gov/bic/) and Neuhausen et al (2008).
Additionally, the results of other controlling variants are consistent with our expectations as well, which further shows that our results are robust.
The effect sizes of the identified variants were consistent across all four cohorts, with seven single nucleotide polymorphisms (SNPs) in FRAP1 (lead SNP: rs17036350, meta P-value = 4.06 × 10 -13 10 -13six SNPs in PDGFRandlead six: rSNPs4039, meta P-value = 1.33 × 10(-9)) attaining genome-wide significance in the SNPDGFRAd meta-analeadSNPf the fours2114039.
Analysis of protein stability, kinetic parameters, solvent isotope effects, and pH-rate profiles for key SrtA variants are consistent with a reverse protonated Cys184-His120 catalytic dyad, and implicate a role for Arg197 in formation of an oxyanion hole to stabilize the transition state.
The direction of effect for both variants is consistent across each individual sample set (Table 2).
Our findings at the DNA sequence level for these variants are consistent to those reported previously [9], [10].
In this respect, the behavior of type I and II-associated variants is consistent with previous studies [27].
Relative protein expression levels between these variants were consistent as protein accumulated during growth phase and were maintained in stationary phase (data not shown).
The absence of a protein concentration dependence for refolding under any conditions for all of the variants is consistent with the rate-limiting unimolecular monomer folding reaction observed for SOD1 [20] [21], [21].
The multiple interspersed phylogenetic positions of VP4/VP2-encoding sequences from HRV-Ca and HRV-Cc variants is consistent with multiple inter-species recombination events in the evolutionary history of human rhinoviruses.
Variants were consistent with the known pattern of inheritance of the respective gene (i.e., homozygous/compound heterozygous or heterozygous).
