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However, analysis of BMI as a continuous trait in the aforementioned case samples demonstrated strong evidence of obesity association with precisely the same variants (trend test P = 8.0 × 10−6).
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Good agreement of the variant trend of the metal hydrogen interaction with that of the enthalpy of formation for each pure dihydride is found, and the ionic and covalent contributions to the metal hydrogen interaction are evaluated quantitatively as a reference for judging their contributions in the alloyed TiH2.
Whites homozygous for the IGF2R C>G01 C>G variant trended towards a higher risk of CC, OR=2.2 [95% CI 0.9 5.4 ], whereas carrying the IGF2R c.5002 G>A variant was not associated with CC risk.
Although a sample of ten individuals across multiple ancestries do not provide reasonable power to achieve statistical significance for identified rare variant trends, it was still useful for showing how BioBin can be used to prioritize bins based on rare variant burden differences.
For non-synonymous variants the trend was similar with an over abundance of variants in the SSTI isolates (SSTI = 522, severe = 455) although this difference did not pass our threshold for significance (p = 0.16).
Yet, when considering only domain-associated variants, a trend toward association was observed in our study and a significant increase in patients was reached in the more powerful meta-analysis dataset.
The results are given as maps representing different variants of trends.
Minor allele genotypes of several MUTYH variants showed trends towards association with lobular BC histology.
Our analysis of nuclear encoded variants shows a trend suggesting the possible involvement of the NDUFS2 gene from Complex I.
Interestingly, we observed several variants with a trend towards a relationship between toxicity and overall survival, and only one SNP was identified as being associated with both.
For example, analysis of the main WTCCC experiment highlighted strong evidence of association of T2D with variants in FTO (trend test P 5 5.2 × 10−8).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com