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Exact(10)
The decision as to which variants to include in the vaccine each year must be made well in advance of the flu season.
We compare two strategies for choosing genetic variants to include in the Mendelian randomization analysis.
One would also need to consider what types of variants to include.
The process for selecting variants to include on a SNP chip is rigorous.
In addition to the question of how to combine genetic variants into profiles, the question arises as to which of the variants to include.
Even with this improvement, various limitations and problems remain unsolved, which include reduced mapping ratios, shifts in read mappings and the selection of which variants to include to remove biases.
Similar(50)
For homogenous multiplicative π [ π (a) = π (i1) π (i2)], at least 4 more exchangeability parameters are required for the TF variant to include the nucleotide GTR.
These results statistically demonstrate a polygenic component to MS susceptibility and suggest that the risk alleles identified to date represent just the tip of an iceberg of risk variants likely to include hundreds of modest effects and possibly thousands of very small effects.
Multiple sclerosis is another disorder with complex inheritance where extensive study suggests 'risk variants likely to include hundreds of modest effects and possibly thousands of very small effects' [ 25].
The raw lists of variants were filtered to include variants within the Sequence Capture target regions (±500 bp).
The regions are combined into per-chromsome multi-sample VCFs, and variants are filtered to include only passing variants using a combination of infoCollctor and vcfCooker.
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CEO of Professional Science Editing for Scientists @ prosciediting.com