Indeed, the decreased risk of female subjects carrying the HLA-A*02 allele and the LMP2 60HH variant to develop MS might be explained by the impact of the LMP2 polymorphism on the generation of the HLA-A*02-restricted epitope (MBP111 119) as well of other epitopes not investigated in this study.
These studies indicate that progressive loss of insulin secretion might be the essential component of the phenotype which predisposes carriers of the TCF7L2 variant to develop type 2 diabetes.
A challenging task will be to insure cross-model validation between the different analogue variants, and to develop appropriate automated validation measures.
This can be considered as a first intention immunosuppression; however it proceeds from immunological exhaustion, since trypanosomes force their host to elicit successive directories of antibodies able to cope with emerging VSG variants, while a new variant is planned to develop before the humoral response is effective [ 168, 169].
Therefore, no evidence for an association of CISH promoter variants and susceptibility to develop T1D was detected.
Because expressed genetic variants have more immediate impact on the protein function compared with the DNA variants, we were motivated to develop a reliable RNA-seq variant prioritization method.
We employed a phage-displayed ubiquitin variant (UbV) library to develop inhibitors targeting the DUBs USP7 and USP10, which are involved in regulating levels of p53 and MDM2.
However, the high conservation among Glu-D3 allelic variants made it difficult to develop allele-specific markers for discriminating different allelic variants.
Here, we report a hetero-micro-seeding strategy for producing high resolution crystals of closely related protein variants, where micro crystals from a readily crystallized variant are used as seeds to develop crystals of other variants less amenable to crystallization.
For instance, targeted mutation breeding of natural or induced variation in the FAD2 gene or mining natural variants has been used to develop crops with high C22 1 or less PUFA [ 38- 40].
