Sentence examples for variants to cause from inspiring English sources

Although the role of both genetic causes and factors that affect the intrauterine environment (such as maternal rubella and teratogen exposure) in human congenital heart disease is well established (reviewed in 17), the mechanisms by which environmental factors interact with genetic variants to cause birth defects is only beginning to be understood (reviewed in 18).

Given the potential for SNP variants to cause changes within the sequences of TFBSs and theoretically impact the binding affinities of TFs, we counted the number of SNP TFBS intersections that were within conserved nucleotides (monomorphic) of the TFBS consensus sequence (Table S1).

Digenic JEB has also been noted, in which compound heterozygous changes in COL17A1 combine with a heterozygous LAMB3 variant to cause JEB, though any two of the mutations described do not suffice to cause the disease.

Accordingly, cancer predisposing germline variants, recurrent cancer somatic mutations, and Mendelian disease variants tend to cause more serious consequences compared to complex disease variants.

We report here the identification of novel AOMT variants likely to cause methylated anthocyanin variation.

Two volunteers had genetic variants known to cause heart rhythm abnormalities, but their cardiology tests were normal.

Some of the mutations appear to be common, while some rare variants seem to cause the same symptoms as those experienced by individuals with a completely different set of rare mutations.

Another plausible candidate is MYH9, which has variants known to cause deafness in humans [28].

Nevertheless, the aim of this study was to ascertain a preliminary frequency of the most common variants known to cause PD in a sub-Saharan population.

Here, we analyze data from 15 years of persistent infection to evaluate pathological and evolutionary characteristics of four HpSVd variants shown to cause mild to severe hop stunt disease.

We did not accept clinically identified variants asserted to cause disease as pathogenic without reported functional data or familial segregation.