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We also compared recommendation rates for clinically significant and benign variants to both broad and narrow characterizations of uncertain results.
Therefore, further studies are needed that relate genetic variants to both early body and lung growth characteristics and respiratory diseases in later life.
A 100 kb region on chromosome 9p21.3 has been recently identified as harboring susceptibility variants to both coronary heart disease (CHD /myocardial infarction [ 1- 5] and to type 2 diabetes (T2D) [ 6, 7] in study populations of European origin.
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Introduction of the mutated covR/S locus transferred the phenotypic appearance of the HH/LC variant to both the LH/HC and NEM316 strains, which resulted in increased hemolytic activity with increased pigmentation and decreased reaction in the CAMP testing.
Overall, the large desolvation energy or hydrophobic effect is the common driver for the dual-specific bH1 variants to engage both HER2 and VEGF and plays a more dominant role in dual interaction than in the Herceptin-HER2 interaction.
The coefficients for the rare variants are estimated from the data, allowing variants to have both risk and protective effects.
Another approach is to conduct whole-genome and whole-exome sequencing of individuals instead of genotyping a catalogue of variants to capture both common and rare variants.
This apoA-I PL interapoA-I PLcurs on the surfaces of both PL-stabinteractionsioccursticles and HDL particles, explaining the strong correlathen in the abilitiesurfacesA-I variants tofboth to both types of particles.
TLR ligands had diverse effects on HIV-1 replication ranging from suppression of both R5 and X4 HIV-1 variants, through differential effects on R5 and X4 HIV-1 variants, to upregulation of both R5 and X4 HIV-1.
In order to be able to assign biological meaning to genomic data, researchers aim to understand the contributions of many sequence variants to phenotypic variation both within and between species.
However, we confirmed the prognostic value of TGFBR2 in the independent POSH study as well as in the Asian samples without study heterogeneity and also showed TGFBR2 variants to be related to both OS and BCSS.
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