Sentence examples for variants to block from inspiring English sources

Preliminary investigations have already revealed that it may be possible to use small peptides or IL-6 variants to block the ability of IL-6 to stimulate aromatase activity.

ΔNΔC-VEGF-C therefore represents the most interesting VEGF-C variant to block.

This possibility is supported by the experimental data which show that this variant fails to block IL22 activity [ 31].

The G89P variant appeared to block the resonance doubling and the conformational linebroadening of the 80′s loop by constraining residue 89 to remain in the cis-peptide configuration with a negative ϕ torsion angle.

The H87V variant appeared to block the resonance doubling and the conformational linebroadening of the 80′s loop by constraining Gly to remain in the trans-peptide configuration with a positive ϕ torsion angle.

These data suggest that EBV may use splicing variants of IRF-7 for its transformation process in two strategies: to use oncogenic properties of various IRF-7 splicing variants, but use one of its splicing variants (IRF-7C) to block the IFN-induction function of IRF-7 that is detrimental for viral transformation.

Thus, EBV may use both IRF-7 splicing variants for its oncogenic transformation, but uses one of its splicing variants (IRF-7C) to block the detrimental IFN-induction function of IRF-7.

Thus, our data collectively suggest that EBV may use splicing variants of IRF-7 for its transformation process in two strategies: to use the oncogenic properties of various IRF-7 splicing variants to promote transformation process, but uses one of its splicing variants (IRF-7C) to block the detrimental function of IRF-7 in IFN-induction.

One theoretical model suggests that mutation occurring in neutral gene variants is sufficient to block their fixation in large populations, leading to a large flux of transient novel sequences (Berg & Kurland, 2002).

Silencing of both Eps15 variants and epsin1 was found to block this alternative pathway demonstrating a role of these three proteins also in this clathrin- independent (Ci) internalization route (fig. 3) [ 68].

However, it might not always be feasible to specifically block such variants when analyzing the sequence, because it could include variants relevant for the diagnostic enquiry, and furthermore, it will be challenging to keep an updated list of all known disease-related variants.