Epidemiological fitness recapitulates several factors that permit a virus type or variant to become dominant in the field.
Thus, under natural selection, beneficial variants tend to become gradually fixed, while detrimental variants tend to be eliminated [ 37].
As in breeding or evolution, the best variants would spread to become the new, proven superior, implementation strategies for that policy in those settings.
The occurrence, and to some extent the severity, of recurrent annual outbreaks, are driven by viral antigenic drift, with an antigenic variant virus emerging to become dominant approximately every 2 to 3 years.
As in breeding or evolution, the evaluation would reveal the best variants, which would spread to become the new, superior, way to implement that policy in those settings.
The ongoing plan is to recruit additional cohorts with data on entrepreneurship and extend our discovery sample to achieve a sufficiently-powered setting to identify common genetic variants underlying the propensity to become an entrepreneur.
Some studies had shown that people with a particular gene variant were more likely to become depressed if they were maltreated as children: the variant created a vulnerability.
Similarly for the D408N variant, D407 is predicted to become protonated only in the O state, while the substituted N408 is evidently neutral throughout the cycle (K940 and R971 are protonated in all states in both mutants).
Age-dependent associations of gene variants have been reported: the genetic influence of obesity risk common variants in FTO was shown to become progressively stronger across lifespan [ 26, 109], whereas gene variation in PCSK1 had more pronounced effects on BMI level and obesity risk in young than in late adulthood [ 63].
