Sentence examples for variants through the from inspiring English sources

In addition, most PDE genes encode for multiple splicing variants through the use of multiple promoters and alternative splicing.

In recent years, new technologies have emerged that allow researchers to further investigate the role of causal variants through the introduction of specific variants into engineered cell lines.

The output is a multi-sample VCF conforming to v 4.1 specifications and includes all variants through the score range (i.e. no filtering is performed by default).

Following the lead of the previous studies, we addressed the issue of trying to detect new colorectal cancer susceptibility variants through the performance of a GWAS in a Spanish cohort.

Only 4 out of 1163 replicates correctly detected association at all five causal variants through the P-value-based meta-analysis, whereas none of the replicates achieved this in the OR-based meta-analysis approaches (Table 2).

This nomenclature system allows flexibility and agnosticism with regard to phylogeny of variants through the long-established use of paralog number suffixes to indicate individual unique variants on an organism-specific basis without implying phylogenetic relationships.

Though extensive work has been carried out to identify the common genetic variants through GWAS, the exact mechanism of the action and role of these genes are yet to be discovered.

A smartass wag might jest that Payne does not understand the dramaturgical principle of draft-exclusion or, to put it slightly more positively, that he has a strong susceptibility to drafts, given the purposeful prevarication of Constellations and its refusal to discriminate amongst the host of hypothetical variants through which the couple in this two-hander travel.

In this context it is interesting that in addition to producing full-length Carf transcripts, we have found that the Carf locus also encodes a C-terminally truncated Carf variant through the use of an alternative polyadenylation site in the intron just following the exons that encode the DNA binding domain [15].

However, since the common variants carry at least some information about rare genetic variants (through linkage disequilibrium), the lack of any detectable overlap presents a challenge to including ASD and ADHD in a single grouping and suggests that their etiologies may need to be studied separately.

Finally, additional genetic associations may be revealed from studies of low-to-intermediate frequency variants through imputation from the 1000 Genomes Project, direct association using whole-genome sequencing data, and in-depth replication and locus fine-mapping through custom arrays.