Sentence examples for variants through a from inspiring English sources

Thus, in this study, we first tested the interactions of the unmodified H3K4 peptide with full-length KDM5B or its truncated variants through a biotin-labeled peptide binding assay.

We hence aimed to find such susceptibility variants through a candidate-gene approach screening a selected number of variants within two cellular pathways that have consistently been linked to CRC tumorogenesis: the Wnt and the BMP signaling pathways [16], [17].

We detected variants through a two-step process.

Moreover, it is unknown if X4 variants emerge from latency many years after an initial independent transmission or, more likely, if they evolve from preexisting R5 variants through a progressive acquisition of a broader receptor affinity [ 9].

However, primary jejunal epithelial cells incubated with HIV-1 carry over only R5 viruses to receptive target cells (Meng et al, 2002), whereas M cells transport selectively X4 viral variants through a chemokine-receptor mediated mechanism (Fotopoulos et al, 2002).

Using a combination of different mouse alleles, we can greatly facilitate the understanding of which candidate gene at a particular disease locus is associated with the disease in humans, and also provide functional analysis of variants through an allelic series, including analysis of hypomorph and hypermorph point mutations, and knockout and overexpression alleles.

For example, our ability to detect a rare causal variant through a GWAS depends not on how much variance the causal variant explains directly, but on the variance explained by the best tagging common SNP, and likewise for loci harbouring interactions.

The World Health Organization (WHO), as well as the US Food and Drug Administration FDA Center for Biologics Evaluation and Researchch, provide annual guidance for strain selection based on new drift variants detected through a global influenza surveillance network [ 8, 9].

Furthermore, the 'weak formulation' was extended to a series of coherent variants through partial integration, rendering a multitude of detection strategies by selecting measurement parameters and configurations.

Following the lead of the previous studies, we addressed the issue of trying to detect new colorectal cancer susceptibility variants through the performance of a GWAS in a Spanish cohort.

Just as haplotype analysis can capture the effect of an untyped causal variant through testing a haplotype that marks (i.e., is a good surrogate for) the untyped causal variant, it seems that imputation can capture the effect of an underlying causal haplotype through testing a SNP that marks this underlying causal haplotype.