Sentence examples for variants the majority from inspiring English sources

Among all the novel variants, the majority (64.31%) are sCNVs (<1 kb in size).

As anticipated, most of these PPVs are missense variants, the majority of which will be classified as variants of unknown significance (VUS) based on existing knowledge (Biesecker, 2012).

Within the seven variants, the majority of variants (four out of seven) were still significant in the Asian-only subsamples, and the other three variants had only been examined in Asian-ancestry samples once or twice previously, precluding definitive answers.

Unlike direct PKD1 mutation testing, where it remains difficult to assign pathogenicity to some variants, the majority of PKD2 sequence variants can be assigned as likely or highly likely to be pathogenic [ 12, 13].

It also underscores the increased specificity of clinical WGS by investigating LoF variants, the majority of which are likely to have similar functional consequences regardless of the genetic heterogeneity of individual genes.

The advent of next generation sequencing has led to an extraordinary acceleration in the discovery rate of rare genetic variants, the majority of which are of uncertain clinical significance.

Intronic variants represent the majority of the variants located in genic regions whereas the regions 5 kb upstream and downstream of a transcript exhibited a total of 772,334 variants.

In three of these cases (20%), the new variant represented the majority variant and in three cases (20%), the new variant was a minority strain.

This very high DST may underestimate the potential functional impact of a variant, since the majority of variants showing a very high DS have never been observed in mtDNA genomes from both healthy and diseased individuals.

Besides the described mRNA variants indicated in Table 1, many more processed variants for the majority of the genes were predicted from the analysis of EST (Expressed Sequence Tag) and SAGE (Serial Analysis of Gene Expression) data.

Despite the current focus on exome sequencing, geneticists appreciate the importance of making sense of genetic variants that fall outside protein-coding regions: a non-trivial fraction of the mutations underlying rare diseases, and variants underlying the majority of the risk of common complex disorders, fall in the 'dark matter' outside the exome.