Sentence examples for variants that predispose from inspiring English sources

The extent of linkage disequilibrium critically determines the efficiency of strategies to identify genetic variants that predispose to human disease.

Here we review and propose how genetically engineered mouse models can serve as valuable tools to predict targeted therapy toxicity, as well as to identify allelic variants that predispose individuals to side effects.

Genome-wide association studies (GWAS) have discovered hundreds of common genetic variants that predispose humans to autoimmune diseases, opening up unprecedented potential for elucidating the pathways and processes of disease.

She said that there may be a hereditary component to the phenomenon that causes some diabetics to be "genetically loaded," with genetic variants that predispose them to diabetes and higher mortality, as well as other illnesses.

Further work will be required to identify additional genetic variants that predispose to Paget's disease and to determine how the causal mutations and predisposing polymorphisms interact with environmental factors to influence bone cell function and cause the focal bone lesions that are characteristic of the disease.

Genome-wide association studies (GWAS) have discovered genetic variants that predispose individuals to asthma.

That is because probably all people carry some gene variants that could predispose them or their children to disease.

Setting up widespread genetic testing in the Yale Epilepsy Center to find genetic variants that may predispose patients to epilepsy.

METHODS: We investigated TERC for variants that may predispose to human NTDs in 477 NTD cases with a variety of phenotypic presentations.

Sequencing of the human genome in 2003 opened the way to identifying specific genes that are involved in particular diseases and thus supports the identification of genetic variants that either predispose an individual to a specific disease or regulate that individual's sensitivity to a given treatment [3].

Genotyping can be applied to human studies to identify genetic variants that may predispose individuals to environmental exposure or disease.