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Six hepatitis A virus antigenic variants that likely escaped the protective effect of available vaccines were isolated, mostly from men who have sex with men.
We omitted array probes from statistical analyses that contained common genetic variants that likely influence DNA binding (Methods), but DNA methylation levels may be mediated by genetic variants in proximity, that is, represent DNA methylation quantitative trait loci (met-QTLs).
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The rs4917 is a nonsynonymous amino acid coding variant that likely affects the transcription of the AHSG protein.
The structural variants that were likely to be missed by WES are more likely to be captured by WGS.
As noted above, we do make an exception for high-throughput assays that attempt to separate variants that are likely to be functional from those are that are likely to be neutral for example, so as to focus burden analysis on the most deleterious variants.
We did not identify any novel rare variants that are likely to have an effect on the protein function.
Any lower threshold significantly increases the number of reported variants that are likely false positives, without adding many true positives (see below).
We also sequenced all those variants that were likely to be SNPs.
Exons 1a and 1b encode different transcript variants that are likely to be initiated from distinct promoters.
Here we provide evidence that a bioinformatic pipeline may be followed in order to identify and prioritise variants that are likely to affect splicing of their host gene.
Our approach succeeds in discriminating between germline variants that are likely to be cancer-associated from those that are related to other genetic disorders.
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