Sentence examples for variants that induce from inspiring English sources

This minigene also allowed us to identify 18 out of 40 variants that induce splicing anomalies.

In the long run, when macroevolution plays a major role, many of these local adaptive changes can be transient, either diminishing as the external pressures are lifted, or being replaced by genetic variants that induce less adverse side effects.

However, in the case of the EpH4 cells, the EMT response to TGF-β requires the expression of Ras variants that induce hyperactivation of the extracellular signal-regulated kinase/MAPK pathway [ 22, 23].

However, the EMT response of the EpH4 cell line to TGF-β requires the expression of Ras variants that induce hyperactivation of the extracellular signal-regulated kinase/MAPK pathway [ 22, 23].

However, on our study, the percentage of patients with this polymorphism was not statistically sufficient to find a relationship with the adverse effects of radiotherapy, even though it is a variant that induces apoptosis.

However, further work is needed on rosetting mechanisms and cross-reactivity in field isolates to define a set of PfEMP1 variants that could induce functional antibodies against a broad range of P. falciparum rosetting parasites.

Beyond baseline nephron number and aging, certain gene variants impose specific risks for premature nephron loss and CKD such as uromodulin gene variants that can induce sodium-sensitive hypertension [ 16– 19], or possibly genes that affect podocyte survival.

Furthermore, given the importance of TRAIL-R2, we hypothesized that the use of TRAIL-R-specific variants that specifically induce apoptosis via TRAIL-R2 might increase the efficacy of the MSC.sTRAIL system further.

Interestingly, the centromere H3 variant appears to form tetrameric nucleosomes that induce positive supercoils, and these specialized 'centromeric nucleosomes' have been proposed as the epigenetic inheritance mechanism for centromeres (20).

Niu, G. et al. Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.

These high-throughput assays show that most variants that impact transcription induce 1.3- to 2-fold differences in target gene expression [ 73, 74].