Sentence examples for variants that impact from inspiring English sources

Generally, we would also expect genetic variants that impact β-cell function to affect the response to insulin secretagogues and genetic variants that impact insulin sensitivity to affect response to insulin sensitizing medications.

Genome-wide association studies have been successful in identifying common variants that impact complex human traits and diseases.

MTHFR is a central regulatory enzyme in folate metabolism and has known variants that impact enzyme function (e.g., rs1801131, rs1801133).

These high-throughput assays show that most variants that impact transcription induce 1.3- to 2-fold differences in target gene expression [ 73, 74].

In particular, deep sequencing has been used to identify medically relevant drug-resistant rare variants that impact anti-retroviral drug treatment outcomes [ 11- 15].

We have reviewed approaches for the identification and interpretation of common-disease-associated variants that impact enhancer function, citing examples in which these methods have been successfully implemented.

However, as with the majority of genetic associations with AD, the functional variants within these loci are unknown; thus, it is even premature to definitively conclude that such association reflects a functional variant that impacts function or expression of the encoded innate immune gene or alternatively alters a neighboring gene or non-coding RNA.

This finding is interesting because it suggests that the link between selenium and depression may be impacted by individual factors, such as genetic variants that may impact the selenium levels in the body.

To further elucidate the role of the TLR-inflammasome-IL-1β cascade in gout pathogenesis, eleven candidate genetic variants that functionally impact on this pathway (reviewed in [ 10]) were tested for association with gout in a sample set of 2,357 cases, adequately powered to detect association with common variants having an effect size of odds ratio 1.4 or greater (Additional file 1).

In the following, I will assume that at a certain point in the future we have indeed obtained a series of DNA variants that strongly impact circadian rhythms or mood regulation, and consider the question: How can these results be useful to neurobiologists to help them explain disease mechanisms?

Expression levels of particular genes have been evaluated as a way of understanding the molecular physiologic impact of genetic variants that may ultimately impact phenotypic expression [ 214].