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The results described in Figure 2 revealed splicing variants that generated three novel exons from the minigenes Δ2, Δ4 and Δ5: Exon 10a from Δ2, Exon 10b from Δ4, and Exon 10c from Δ5.
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The company blamed the introduction of lower-priced Model 3 variants that generate less profit than costlier versions, price cuts on the vehicles it exports to China and fewer sales of emissions credits to other carmakers.
We also do not consider variants that generate new motif sites.
Using low fidelity CVB3 variants that generate subtle, yet biologically confirmed, differences in mutant composition, we showed that detected variation frequencies correlated with the mutation frequencies obtained by molecular cloning in the original paper (Gnädig et al., 2012).
The CYP2C19*2 SNP results in an aberrant splice variant that generates an alternative reading frame and a premature stop codon (Demorais et al, 1994).
It is observed that this strategy can greatly improve the number of functional variants that are generated as well as the average number of mutations that can be made in the library.
TBX5 encodes 4 transcript variants that are generated by alternate transcription initiation sites and alternative splicing.
These filters removed false positive variants that were generated by genomic features resulting in mapping errors or systematic sequencing artefacts.
In these, the new variants that are generated, by either host or parasite, are not limited to those that are directly tailored to the particular situation.
Fig. 1 illustrates the C-tail sequence of TPα and its mutated variants that were generated and used in this study.
Although this may indicate that positive selection contributes to fixation of new allelic variants that were generated by recombination [ 18], it may also reflect that the positive selection tests were affected by intragenic recombination [ 52].
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