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Thus, the findings provide a new glimpse into the ways that early farmers might have inadvertently begun to domesticate animals, possibly by choosing to stable less aggressive animals and thus favoring genetic variants that eventually led to domesticated varieties.
In a recent study, the authors focused on such earlier population (500th generation of the experiment) and compared the fitness of two clones with gene variants that eventually took over the population, with the fitness of two other contemporary clones that lacked the particular variants and went extinct in the original experiment (Woods et al. 2011).
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The F-35 is being developed in three variants that will eventually be used by the US Air Force, Navy, Marine Corps, as well as eight other countries that have committed to buying the aircraft and are helping to pay for its development.
However, except Q3LW11 of Gag QW11 (Figure 8C), the cross-recognized variants that were eventually nearly fixed (EL9 of Vpr EI9, Y2D5AW9 of Env YW9, N3GY9 of PolNY9, and TT8 of Pol TI8; Figures 7 and 8A) had avidities more than 10 fold lower than their founder epitopes (Table S1).
The exchange of sequence between superfamilies produces structural variants that can eventually compete with each other and evolve as separate entities.
For example, some genomic regions may be more highly mutable than others and so are more likely to generate variants that are eventually selected during adaptive evolution.
The variants that are discovered may eventually prove valuable as family based genetic tests.
Eventually, the true functional variants that confer susceptibility to type I diabetes were shown to arise from the HLA class II region, a megabase away from the those variants originally shown to associate with disease.
There is a tremendous body of literature that supports the hypothesis that cancer results from the slow accumulation of mutations that eventually give rise to rare variant cells with metastatic potential.
Future studies utilizing the rapidly increasing power of genome sequencing technologies to interrogate a much wider range of candidate genes, and eventually the whole exome, for rare variants that predispose to CVM will be of great interest.
These might eventually contribute to the identification of the selected variants that caused the signatures found.
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